Water → 4,4-Diphenylbutyl methanesulfonate

HRID 565651ノート

反応式

HRID 565651 の反応式
[C:1]1([CH:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:8][CH2:9][CH2:10][OH:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.[CH3:19][S:20](Cl)(=[O:22])=[O:21]>ClC(Cl)C.C(N(CC)CC)C>[CH3:19][S:20]([O:11][CH2:10][CH2:9][CH2:8][CH:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)(=[O:22])=[O:21]

参加物

6

反応物 3

HCID 962WaterHCID 31297Methanesulfonyl chlorideHCID 925194,4-Diphenylbutan-1-ol

生成物 1

HCID 138807014,4-Diphenylbutyl methanesulfonate収率 99%

試薬・触媒・溶媒 2

HCID 63651,1-Dichloroethane溶媒HCID 8471Triethylamine溶媒

実験手順

To an iced-cooled solution of 4,4-diphenyl-1-butanol (5.6 g) in dichloroethane (100 mL), 11 mL of triethylamine and 2.9 mL of methanesulfonyl chloride were added dropwise in the order mentioned. After 30 minutes of stirring, the reaction mixture was poured into water and extracted with ethyl acetate. The extract was washed with saturated aqueous NaCl, dried over MgSO4, and concentrated to provide 7.5 g of the title compound. Yield 99%.

後処理

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with saturated aqueous NaCl
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-c9ddfde998e143e8bc06e50cd97540c8
出典データセット
uspto-grants-2001_01
特許番号
US06172085B2

反応ノート

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