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Indole → 1-Phenyl-1H-indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Indole | HCID 798 | — |
| 反応物 | Potassium Bicarbonate | HCID 516893 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 溶媒 | Bromobenzene | HCID 7961 | — |
| 生成物 | 1-Phenyl-1H-indole | HCID 182029 | 124.2% |
反応手順
A suspension of indole (8.2 g), potassium bicarbonate (12 g) and copper (I) iodide (2.7 g) in bromobenzene (70 mL) was refluxed for 3 hours under nitrogen atmosphere. To the mixture copper (I) iodide (11 g) was added and the mixture was refluxed for additional 6 hours. The insoluble material was removed by filtration and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=50:1 to 20:1) to provide 8.4 g of the title compound. Yield 62%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06172085B2 |
| 出典データセット | uspto-grants-2001_01 |
| ORD ID | ord-df943a1910d34487b1cad511b5518662 |
| 出典メモ | uspto-grants-2001_01 |