N-Methylbutylamine → N-butyl-5-chloro-N-methyl-pentanesulfonamide

反応式

[CH3:1][NH:2][CH2:3][CH2:4][CH2:5][CH3:6].[Cl:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][S:13](Cl)(=[O:15])=[O:14]>>[CH2:3]([N:2]([CH3:1])[S:13]([CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][Cl:7])(=[O:15])=[O:14])[CH2:4][CH2:5][CH3:6]

参加物

反応物 2

HCID 8068N-Methylbutylamine

HCID 12589202HCID 12589202、化合物

生成物 1

HCID 19711033N-butyl-5-chloro-N-methyl-pentanesulfonamide収率 92.8%

実験手順

The reaction was carried out in the same manner as in Preparation Example 11 except for using N-methyl-n-butylamine (5.75g, 66 mmol) in place of diethylamine, and 5-chloropentanesulfonyl chloride (6.15g, 30 mmol) in place of 6-chlorohexanesulfonyl chloride in Preparation Example 11, to give N-n-butyl-N-methyl-5-chloropentanesulfonamide (7.12 g) as a pale yellow oil.

後処理

customThe reaction was carried out in the same manner as in Preparation Example 11 except
customin Preparation Example 11

出典と根拠

ORDレコード: ord-4feb31bbe46c41c39782bcc569bca7c1
出典データセット: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06172228B2

反応ノート

読み込み中…

参加物