Cyclopropylamine → N-cyclopropyl-10-bromodecanesulfonamide

HRID 565742ノート

反応式

HRID 565742 の反応式
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][S:12](Cl)(=[O:14])=[O:13].[CH:16]1([NH2:19])[CH2:18][CH2:17]1>>[CH:16]1([NH:19][S:12]([CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][Br:1])(=[O:14])=[O:13])[CH2:18][CH2:17]1

参加物

3

反応物 2

HCID 69828CyclopropylamineHCID 1867984510-Bromodecanesulfonyl chloride

生成物 1

HCID 22111539N-cyclopropyl-10-bromodecanesulfonamide収率 97.3%

実験手順

The reaction was carried out in the same manner as in Preparation Example 3 except for using 10-bromodecanesulfonyl chloride (450 mg, 1.41 mmol) in place of 6-bromohexanesulfonyl chloride, and cyclopropylamine (177 mg, 3.10 mmol), to give N-cyclopropyl-10-bromodecanesulfonamide (467 mg) as colorless crystals.

後処理

  1. customThe reaction was carried out in the same manner as in Preparation Example 3 except

出典と根拠

ORDレコード
ord-31ac275ffe3b42b1bc5420bd7b949d33
出典データセット
uspto-grants-2001_01
特許番号
US06172228B2

反応ノート

読み込み中…