Stannous chloride dihydrate → 2,3-Dimethyl-4-hydrazinobenzoic acid hydrochloride

関与物質

反応条件

反応手順

A solution of 1.87 g of NaNO2 in 7 ml of water is added slowly to a solution, cooled to −5° C., of 4.5 g of 4-amino-2,3-dimethylbenzoic acid in 135 ml of concentrated HCl . After 2 hours of stirring at −5° C., a solution of 25 g of SnCl2.2H2O in 250 ml of concentrated HCl is added at −10° C., and the mixture is stirred for 30 minutes at −5° C. and then 2 hours at RT. The mixture is filtered, and the precipitate is washed with 5 ml of concentrated HCl and dried under a stream of dry nitrogen and then under vacuum to obtain 5.5 g of expected product.

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