関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 5-Amino-2-chlorobenzoic acid | HCID 37879 | — |
| 反応物 | Stannous chloride dihydrate | HCID 61436 | — |
| 反応物 | Sodium Nitrite | HCID 23668193 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-Chloro-5-hydrazinylbenzoic acid hydrochloride | HCID 16495725 | 123.1% |
反応手順
A solution of 2.11 g of NaNO2 in 40 ml of water is added over 30 minutes to a suspension, cooled to −2° C., of 5 g of 5-amino-2-chlorobenzoic acid in 50 ml of concentrated HCl. The solution is stirred for 2 hours at −3° C. and cooled to −10° C., and a solution of 23 g of SnCl2.2H2O in 20 ml of concentrated HCl and 20 ml of water is added over 30 minutes. The mixture is stirred for one and a half hours at 0° C. and filtered, and the precipitate is dried to obtain 4 g of expected product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06172239B2 |
|---|
| 出典データセット | uspto-grants-2001_01 |
|---|
| ORD ID | ord-fd6f079ef34b4c6a9e61fec9a095b282 |
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| 出典メモ | uspto-grants-2001_01 |
|---|
