1-[2-(4-Nitrophenyl)ethyl]piperidine → 4-(2-(Piperidin-1-yl)ethyl)aniline

HRID 565844

反応式

HRID 565844 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:6][CH:5]=1)([O-])=O>C(O)C>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:6][CH:5]=1

参加物

3

反応物 1

HCID 2205731-[2-(4-Nitrophenyl)ethyl]piperidine

生成物 1

HCID 107034004-(2-(Piperidin-1-yl)ethyl)aniline収率 100.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

In ethanol (100 ml) was dissolved 1-[2-(4-nitrophenyl)ethyl]piperidine (24.8 g), and to the mixture was added dried 10% palladium on carbon (1.24 g). Under hydrogen atmosphere, the mixture was stirred at room temperature under atmospheric pressure for 86 hours. The palladium was filtered off, and the filtrate was concentrated to give 1-[2-(4-aminophenyl)ethyl]-piperidine (21.7 g) as pale brown oil.

後処理

  1. additionto the mixture was added
  2. dry with materialdried 10% palladium on carbon (1.24 g)
  3. filtrationThe palladium was filtered off
  4. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-18e902232dcb47e092700ab5db58a929
出典データセット
uspto-grants-2001_01
特許番号
US06172061B2

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