tert-Butyldimethyl((4-nitrobenzyl)oxy)silane → 4-Aminobenzyloxy-tert-butyldimethylsilane

HRID 565854ノート

反応式

HRID 565854 の反応式
[C:1]([Si:5]([CH3:18])([CH3:17])[O:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][CH:9]=1)([CH3:4])([CH3:3])[CH3:2]>C(O)C>[NH2:14][C:11]1[CH:12]=[CH:13][C:8]([CH2:7][O:6][Si:5]([C:1]([CH3:2])([CH3:3])[CH3:4])([CH3:17])[CH3:18])=[CH:9][CH:10]=1

参加物

3

反応物 1

HCID 11065418tert-Butyldimethyl((4-nitrobenzyl)oxy)silane

生成物 1

HCID 110754704-Aminobenzyloxy-tert-butyldimethylsilane収率 94.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

In ethanol (80 ml) was dissolved tert-butyldimethyl-4-nitrobenzyloxysilane (16.5 g), and to the mixture was added dried 5% palladium on carbon (0.83 g). Under hydrogen atmosphere, the mixture was stirred at room temperature under atmospheric pressure for 7.5 hours. The palladium was filtered off, and the filtrate was concentrated. The residue was separated and purified with column chromatography (ethyl acetate/hexane=1/4) to give 4-aminobenzyloxy-tert-butyldimethylsilane (13.8 g) as colorless oil.

後処理

  1. additionto the mixture was added
  2. dry with materialdried 5% palladium on carbon (0.83 g)
  3. filtrationThe palladium was filtered off
  4. concentrationthe filtrate was concentrated
  5. customThe residue was separated
  6. custompurified with column chromatography (ethyl acetate/hexane=1/4)

出典と根拠

ORDレコード
ord-146cb188867747b6912f13ae57baacf6
出典データセット
uspto-grants-2001_01
特許番号
US06172061B2

反応ノート

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