2-Thiopheneboronic acid → 2-(4-Bromo-3,5-dimethoxyphenyl)thiophene

反応式

[Br:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5](I)=[CH:4][C:3]=1[O:11][CH3:12].[S:13]1[CH:17]=[CH:16][CH:15]=[C:14]1B(O)O>>[Br:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([C:14]2[S:13][CH:17]=[CH:16][CH:15]=2)=[CH:4][C:3]=1[O:11][CH3:12]

参加物

反応物 2

HCID 27339602-Thiopheneboronic acid

HCID 584320782-Bromo-5-iodo-1,3-dimethoxybenzene

生成物 1

HCID 584320092-(4-Bromo-3,5-dimethoxyphenyl)thiophene

実験手順

2-(4-Bromo-3,5-dimethoxyphenyl)thiophene was prepared from 2-bromo-5-iodo-1,3-dimethoxybenzene and thiophen-2-ylboronic acid according to the procedure used in Example 12. Purification by chromatography (0-10% EtOAc-hexanes) gave a yellow solid (0.624 g, 55% yield).

後処理

customPurification by chromatography (0-10% EtOAc-hexanes)

出典と根拠

ORDレコード: ord-eecc77cbd6d7424caedab291ca060b73
出典データセット: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09434707B2

反応ノート

読み込み中…

参加物