7-(4-dimethylaminophenyl)-N-(4-((1-oxophosphorinan-1-yl)methyl)phenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide → 7-(4-dimethylaminophenyl)-N-(4-((1-oxophosphorinan-1-yl)methyl)phenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide hydrochloride
反応式
[CH3:1][N:2]([CH3:37])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[CH:11][C:12]3[O:18][CH2:17][CH2:16][C:15]([C:19]([NH:21][C:22]4[CH:27]=[CH:26][C:25]([CH2:28][P:29]5(=[O:35])[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]5)=[CH:24][CH:23]=4)=[O:20])=[CH:14][C:13]=3[CH:36]=2)=[CH:5][CH:4]=1.[ClH:38].C(OCC)(=O)C>C(O)C>[ClH:38].[CH3:1][N:2]([CH3:37])[C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[CH:11][C:12]3[O:18][CH2:17][CH2:16][C:15]([C:19]([NH:21][C:22]4[CH:27]=[CH:26][C:25]([CH2:28][P:29]5(=[O:35])[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]5)=[CH:24][CH:23]=4)=[O:20])=[CH:14][C:13]=3[CH:36]=2)=[CH:7][CH:8]=1参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
To a solution of 7-(4-dimethylaminophenyl)-N-(4-((1-oxophosphorinan-1-yl)methyl)-phenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide (0.1g) in ethanol was added 4 N hydrochloric acid-ethyl acetate (0.2ml) under ice-cooling. The solvent was evaporated, and the residue was crystallized from ethanol and diethylether to give 7-(4-dimethylamino-phenyl)-N-(4-((1-oxophosphorinan-1-yl)methyl)phenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide hydrochloride (Compound 155) (0.1g) as colorless crystals.