N-(2-methoxyethyl)-N-methyl-4-nitrobenzylamine → 4-{[(2-Methoxyethyl)methylamino]methyl}phenylamine

HRID 566138ノート

反応式

HRID 566138 の反応式
[CH3:1][O:2][CH2:3][CH2:4][N:5]([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][CH:9]=1)[CH3:6]>C(O)(=O)C>[CH3:1][O:2][CH2:3][CH2:4][N:5]([CH2:7][C:8]1[CH:9]=[CH:10][C:11]([NH2:14])=[CH:12][CH:13]=1)[CH3:6]

参加物

3

反応物 1

HCID 23507717N-(2-methoxyethyl)-N-methyl-4-nitrobenzylamine

生成物 1

HCID 235074614-{[(2-Methoxyethyl)methylamino]methyl}phenylamine収率 66.5%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

In acetic acid (100 ml) was dissolved N-(2-methoxyethyl)-N-methyl-4-nitrobenzylamine (5.9 g), and to the mixture was added reduced iron (7.5 g) little by little. The mixture was stirred at room temperature overnight, and the solvent was evaporated. To the residue was added ethyl acetate, and precipitates were filtered off. The filtrate was washed with sodium hydroxide solution, water and saturated brine, and dried with anhydrous magnesium sulfate. Under reduced pressure, the solvent was evaporated to give 4-((N-(2-methoxyethyl)-N-methylamino)methyl)aniline (3.4 g) as red oil.

後処理

  1. customthe solvent was evaporated
  2. additionTo the residue was added ethyl acetate
  3. customprecipitates
  4. filtrationwere filtered off
  5. washThe filtrate was washed with sodium hydroxide solution, water and saturated brine
  6. dry with materialdried with anhydrous magnesium sulfate
  7. customUnder reduced pressure, the solvent was evaporated

出典と根拠

ORDレコード
ord-cf5fe72536324a2990b0a1993d65aa7d
出典データセット
uspto-grants-2001_01
特許番号
US06172061B2

反応ノート

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