Sodium Methoxide → 2-(6-Amino-2-pyridyl)ethanethiol

HRID 566242ノート

反応式

HRID 566242 の反応式
C([S:4][CH2:5][CH2:6][C:7]1[N:12]=[C:11]([NH2:13])[CH:10]=[CH:9][CH:8]=1)(=O)C.C[O-].[Na+]>CO.Cl>[NH2:13][C:11]1[N:12]=[C:7]([CH2:6][CH2:5][SH:4])[CH:8]=[CH:9][CH:10]=1

参加物

5

反応物 2

HCID 10942334Sodium MethoxideHCID 212658556-(2-Acetylthioethyl)-2-pyridylamine

生成物 1

HCID 212657842-(6-Amino-2-pyridyl)ethanethiol

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒2 回

実験手順

6-(2-Acetylthioethyl)-2-pyridylamine (0.56 g) was dissolved in methanol (10 ml). To the solution was added, at 0° C., sodium methylate (a 4.9N methanol solution, 0.58 ml), and the mixture was stirred for 30 minutes. To the reaction mixture was added iN hydrochloric acid (2.85 ml), followed by concentration under reduced pressure. To the concentrate was added ethyl acetate (10 ml), which was subjected to extraction. The extract solution was dried over anhydrous magnesium sulfate, followed by concentration to leave the title compound as an oily product (0.43 g).

後処理

  1. additionTo the solution was added, at 0° C.
  2. concentrationfollowed by concentration under reduced pressure
  3. additionTo the concentrate was added ethyl acetate (10 ml), which
  4. extractionwas subjected to extraction
  5. dry with materialThe extract solution was dried over anhydrous magnesium sulfate
  6. concentrationfollowed by concentration

出典と根拠

ORDレコード
ord-96f7ca40286f450c9f28596ebf21dfb0
出典データセット
uspto-grants-2001_01
特許番号
US06174877B1

反応ノート

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