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tert-Butyl 2-bromopropanoate → tert-Butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)propanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butyl 2-bromopropanoate | HCID 545327 | — |
| 反応物 | 4-Bromo-2-hydroxypyridine | HCID 817115 | — |
| 生成物 | tert-Butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)propanoate | HCID 117622807 | — |
反応手順
6.0 g (34.5 mmol) of 4-bromopyridin-2(1H)-one and 7.9 g (37.9 mmol) of tert-butyl 2-bromopropanoate (racemate) were reacted according to General Method 4B. After removal of the DMF, the desired product was precipitated with water and then purified further by flash chromatography (silica gel 60, mobile phase: cyclohexane/ethyl acetate mixtures). Yield: 7.4 g (69% of theory)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434690B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-a3d9a6c70f324a2bbe12ad35708693af |
| 出典メモ | uspto-grants-2016_09 |