2-(4-Methylphenyl)acetyl chloride → 1-[1-(1-Hydroxy-ethyl)-4-phenyl-butyl]-6-(4-methyl-benzyl)-1,5-dihydro-pyrazolo[3,4-d]-pyrimidin-4-one

HRID 566329

反応式

HRID 566329 の反応式
[NH2:1][C:2]1[N:6]([CH:7]([CH:17]([OH:19])[CH3:18])[CH2:8][CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:5]=[CH:4][C:3]=1[C:20]([NH2:22])=[O:21].[CH3:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30][C:31](Cl)=O)=[CH:26][CH:25]=1>>[OH:19][CH:17]([CH:7]([N:6]1[C:2]2[N:1]=[C:31]([CH2:30][C:27]3[CH:28]=[CH:29][C:24]([CH3:23])=[CH:25][CH:26]=3)[NH:22][C:20](=[O:21])[C:3]=2[CH:4]=[N:5]1)[CH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[CH3:18]

参加物

3

反応物 2

HCID 27606342-(4-Methylphenyl)acetyl chlorideHCID 212660785-Amino-1-[1-(1-hydroxy-ethyl)-4-phenyl-butyl]-1H-pyrazole-4-carboxamide

生成物 1

HCID 1357028671-[1-(1-Hydroxy-ethyl)-4-phenyl-butyl]-6-(4-methyl-benzyl)-1,5-dihydro-pyrazolo[3,4-d]-pyrimidin-4-one

実験手順

Starting from 400 g (1.32 mmol) of 5-amino-1-[1-(1-hydroxy-ethyl)-4-phenyl-butyl]-1H-pyrazole-4-carboxamide and 578 mg (3.44 mmol) of 4-methylphenylacetylchloride, the title compound is prepared analogously to the protocol of Example 13. This gives 117 mg (21%) of the diastereomer which elutes more rapidly, M.p.: 133° C., and 75 mg (13.6%) of the diastereomer which elutes more slowly, M.p.: 136° C.

出典と根拠

ORDレコード
ord-5eb603e79f8740839897d3edc2d695b6
出典データセット
uspto-grants-2001_01
特許番号
US06174884B1

関連ノート

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