Benzeneacetic acid, 3,4-dimethoxy-, methyl ester → HCID 136110485、化合物

HRID 566367ノート

反応式

HRID 566367 の反応式
[NH2:1][C:2]1[N:6]([CH:7]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[CH2:8][CH2:9][CH3:10])[N:5]=[C:4]([CH2:17][CH2:18][CH3:19])[C:3]=1[C:20]([NH2:22])=[O:21].[CH3:23][O:24][C:25]1[CH:26]=[C:27]([CH2:33][C:34](OC)=O)[CH:28]=[CH:29][C:30]=1[O:31][CH3:32].CC(C)([O-])C.[K+].C(=O)([O-])O.[Na+]>ClCCl>[CH3:23][O:24][C:25]1[CH:26]=[C:27]([CH:28]=[CH:29][C:30]=1[O:31][CH3:32])[CH2:33][C:34]1[NH:22][C:20](=[O:21])[C:3]2[C:4]([CH2:17][CH2:18][CH3:19])=[N:5][N:6]([CH:7]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[CH2:8][CH2:9][CH3:10])[C:2]=2[N:1]=1

参加物

6

反応物 4

HCID 85213Benzeneacetic acid, 3,4-dimethoxy-, methyl esterHCID 516892Sodium BicarbonateHCID 23665647Potassium tert-butoxideHCID 59932330HCID 59932330、化合物

生成物 1

HCID 136110485HCID 136110485、化合物収率 74.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

6 mg (0.019 mmol) of 5-amino-3-propyl-1-(4-decyl)-1H-pyrazole-4-carboxamide and 20 mg (0.095 mmol) of methyl 3,4-dimethoxyphenylacetate are refluxed for 6 hours in 0.3 ml of a 0.5M ethanolic potassium tert-butoxide solution. After dichloromethane and saturated aqueous sodium hydrogen carbonate have been added, the phases are separated. Purification by chromatography gives 6.6 mg (68%) of a solid, Rf=0.25 (dichloromethane/methanol=15:1).

後処理

  1. customthe phases are separated
  2. customPurification by chromatography

出典と根拠

ORDレコード
ord-29e87a93cc2749da8f5202092b726f94
出典データセット
uspto-grants-2001_01
特許番号
US06174884B1

反応ノート

読み込み中…