Sodium Bicarbonate → HCID 135966561、化合物

HRID 566369ノート

反応式

HRID 566369 の反応式
[NH2:1][C:2]1[N:6]([CH:7]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[CH2:8][CH2:9][CH3:10])[N:5]=[C:4]([CH2:17][CH2:18][CH3:19])[C:3]=1[C:20]([NH2:22])=[O:21].[CH3:23][N:24]1[CH2:29][CH2:28][N:27]([S:30]([CH:33]([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[C:34](OC)=O)(=[O:32])=[O:31])[CH2:26][CH2:25]1.CC(C)([O-])C.[K+].C(=O)([O-])O.[Na+]>ClCCl>[CH3:23][N:24]1[CH2:25][CH2:26][N:27]([S:30]([CH:33]([C:34]2[NH:22][C:20](=[O:21])[C:3]3[C:4]([CH2:17][CH2:18][CH3:19])=[N:5][N:6]([CH:7]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[CH2:8][CH2:9][CH3:10])[C:2]=3[N:1]=2)[C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)(=[O:32])=[O:31])[CH2:28][CH2:29]1

参加物

6

反応物 4

HCID 516892Sodium BicarbonateHCID 23665647Potassium tert-butoxideHCID 59932330HCID 59932330、化合物HCID 70222736methyl 4-N-methylpiperazinosulphonylphenylacetate

生成物 1

HCID 135966561HCID 135966561、化合物収率 36.9%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

6 mg (0.019 mmol) of 5-amino-3-propyl-1-(4-decyl)-1H-pyrazole-4-carboxamide and 20 mg (0.064 mmol) of methyl 4-N-methylpiperazinosulphonylphenylacetate are refluxed for 6 hours in 0.3 ml of a 0.5M ethanolic potassium tert-butoxide solution. After dichloromethane and saturated aqueous sodium hydrogen carbonate have been added, the phases are separated. Purification by chromatography gives 4 mg (36%) of a solid, Rf=0.16 (dichloromethane/methanol=15:1).

後処理

  1. customthe phases are separated
  2. customPurification by chromatography

出典と根拠

ORDレコード
ord-5435ff74da5845459bedd7396ff5bd19
出典データセット
uspto-grants-2001_01
特許番号
US06174884B1

反応ノート

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