関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl benzoylformate | HCID 15349 | — |
| 反応物 | 1-Benzyl-4-piperidylamine | HCID 415852 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-(1-benzyl-4-piperidinyl)phenyl-glyoxylic acid amide | HCID 11120838 | 81.4% |
反応手順
Added to 4.28 g of ethyl phenylglyoxylate were 9.12 g of 4-amino-1-benzylpiperidine. The mixture was heated and stirred at 120° C. for 3 hours on an oil bath. Thereafter, ethanol formed was distilled off under reduced pressure, and the residue was purified by column chromatography on silica gel, thereby obtaining 6.3 g (yield: 81.4%) of N-(1-benzyl-4-piperidinyl)phenyl-glyoxylic acid amide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06174900B1 |
|---|
| 出典データセット | uspto-grants-2001_01 |
|---|
| ORD ID | ord-647897c87c744c8bb37ca0405e06145b |
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| 出典メモ | uspto-grants-2001_01 |
|---|
