Acetic Anhydride → 6-(5-Methyl-1,3,4-oxadiazol-2-yl)-pyrido[3,4-d]pyrimidin-4-one

反応式

N1[C:5]([C:6]2[N:16]=[CH:15][C:9]3[N:10]=[CH:11][NH:12][C:13](=[O:14])[C:8]=3[CH:7]=2)=[N:4][N:3]=N1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>>[CH3:18][C:17]1[O:19][C:5]([C:6]2[N:16]=[CH:15][C:9]3[N:10]=[CH:11][NH:12][C:13](=[O:14])[C:8]=3[CH:7]=2)=[N:4][N:3]=1

参加物

反応物 2

HCID 7918Acetic Anhydride

HCID 178518713HCID 178518713、化合物

生成物 1

HCID 1358174476-(5-Methyl-1,3,4-oxadiazol-2-yl)-pyrido[3,4-d]pyrimidin-4-one

実験手順

6-(1,2,3,4-Tetrazol-5-yl)-pyrido[3,4-d]pyrimidin-4-one (1.4 g) in acetic anhydride (10 ml) was heated at reflux under N2 for 2.5 hours. The cooled mixture was absorbed onto silica and purified by chromatography to give the title compound 90.14 g) as a beige solid; δH [2H6]DMSO 13.0(1H,bs), 9.30 (1H,s), 8.66 (1H,s), 8.47 (1H,s) 2.75 (3H,s); m/z (M+1+)230.

後処理

temperatureat reflux under N2 for 2.5 hours
customThe cooled mixture was absorbed onto silica
custompurified by chromatography

出典と根拠

ORDレコード: ord-559d1d2348d94bf3a8cbb08d9107386b
出典データセット: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06174889B1

反応ノート

読み込み中…

参加物