関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Tetradecylamine | HCID 16217 | — |
| 反応物 | Tetrahydrophthalic anhydride, cis- | HCID 98495 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 6-(Hydroxymethyl)-N-tetradecyl-3-cyclohexene-1-carboxamide | HCID 21266158 | 93.1% |
反応手順
1-Tetradecylamine (3.51 g) was added to cis-4-cyclohexene-1,2-dicarboxylic anhydride (2.50 g) and stirred for 5 hours at 140° C. The reaction mixture was suspended into a mixed solution of 2-propanol (125 ml) and water (21 ml) and then sodium borohydride (3.11 g) was added thereto at room temperature. After being stirred for 67.5 hours at room temperature, the reaction mixture was acidified with dilute hydrochloric acid. The resulting solid was collected by filtration under a vacuum, washed with water, and dried, thereby yielding the entitled compound (5.38 g) as white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06174885B1 |
|---|
| 出典データセット | uspto-grants-2001_01 |
|---|
| ORD ID | ord-478abe3bf9a9404bbfcca86e0ea2e081 |
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| 出典メモ | uspto-grants-2001_01 |
|---|
