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4-Bromo-2-hydroxypyridine → tert-Butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)butanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Bromo-2-hydroxypyridine | HCID 817115 | — |
| 反応物 | tert-Butyl 2-bromobutanoate | HCID 13124118 | — |
| 生成物 | tert-Butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)butanoate | HCID 117622861 | — |
反応手順
348 mg (2.0 mmol) of 4-bromopyridin-2(1H)-one and 1.2 eq. of tert-butyl 2-bromobutanoate (racemate) were reacted according to General Method 4B at 120° C. After aqueous work-up, the desired product was reacted further as crude product. Yield: 608 mg (purity 82%, 79% of theory)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434690B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-14b2ea9e819e44e5aba150649ad2e6ec |
| 出典メモ | uspto-grants-2016_09 |