関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Lithium Bromide | HCID 82050 | — |
| 反応物 | 4-Bromo-2-hydroxypyridine | HCID 817115 | — |
| 反応物 | Ethyl 3-cyclopropyl-2-[(methylsulphonyl)oxy]propanoate | HCID 117605475 | — |
| 生成物 | Ethyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-cyclopropylpropanoate | HCID 117622870 | — |
反応手順
1.02 g (5.87 mmol) of 4-bromopyridin-2(1H)-one and 2.23 g (purity 56%, 5.28 mmol) of ethyl 3-cyclopropyl-2-[(methylsulphonyl)oxy]propanoate (racemate) in the presence of 1.15 eq. of sodium hydride and 2.3 eq. of lithium bromide were reacted according to General Method 4C (stirred at 65° C. overnight). Yield: 246 mg (13% of theory)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09434690B2 |
|---|
| 出典データセット | uspto-grants-2016_09 |
|---|
| ORD ID | ord-e4b0243d8a54422bb0021d2b39bd193f |
|---|
| 出典メモ | uspto-grants-2016_09 |
|---|
