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Benzoic acid, 4-amino-, 1,1-dimethylethyl ester → tert-Butyl 4-{[2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-cyclopropylpropanoyl]amino}benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoic acid, 4-amino-, 1,1-dimethylethyl ester | HCID 233272 | — |
| 反応物 | 2-(4-Bromo-2-oxopyridin-1(2H)-yl)-3-cyclopropylpropanoic acid | HCID 117622547 | — |
| 生成物 | tert-Butyl 4-{[2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-cyclopropylpropanoyl]amino}benzoate | HCID 117622557 | — |
反応手順
290 mg (purity 94%, 0.95 mmol) of 2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-cyclopropylpropanoic acid (racemate) and 1.1 eq. of tert-butyl 4-aminobenzoate were reacted according to General Method 5A. Yield: 114 mg (purity 80%, 21% of theory)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434690B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-af942e16b44b47fdb42c1a87322408b8 |
| 出典メモ | uspto-grants-2016_09 |