関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Lithium Bromide | HCID 82050 | — |
| 反応物 | 4-Bromo-2-hydroxypyridine | HCID 817115 | — |
| 反応物 | Ethyl 2-bromo-3-phenylpropanoate | HCID 4737529 | — |
| 生成物 | Ethyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-phenylpropanoate | HCID 117622558 | — |
反応手順
544 mg (3.13 mmol) of 4-bromopyridin-2(1H)-one and 845 mg (3.3 mmol) of ethyl 2-bromo-3-phenylpropanoate (racemate) in the presence of 1.15 eq. of sodium hydride and 2.3 eq. of lithium bromide were reacted according to General Method 4C (stirred at 65° C. for 1.5 h). Yield: 572 mg (51% of theory)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09434690B2 |
|---|
| 出典データセット | uspto-grants-2016_09 |
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| ORD ID | ord-2da1cfbee0a04af5a39d8083688e43f8 |
|---|
| 出典メモ | uspto-grants-2016_09 |
|---|
