tert-Butyl bromoacetate → tert-Butyl (4-bromo-2-oxopyridin-1(2H)-yl)acetate

HRID 56680ノート

反応式

HRID 56680 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][NH:5][C:4](=[O:8])[CH:3]=1.Br[CH2:10][C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12]>>[Br:1][C:2]1[CH:7]=[CH:6][N:5]([CH2:10][C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[C:4](=[O:8])[CH:3]=1

参加物

3

反応物 2

HCID 79177tert-Butyl bromoacetateHCID 8171154-Bromo-2-hydroxypyridine

生成物 1

HCID 117622649tert-Butyl (4-bromo-2-oxopyridin-1(2H)-yl)acetate

実験手順

4.9 g (28.4 mmol) of 4-bromopyridin-2(1H)-one and 1.2 eq. of tert-butyl 2-bromoacetate were reacted according to General Method 4B at 120° C. After aqueous work-up, the crude product was reacted further without further purification. Yield: 8.6 g (purity 91%, 95% of theory)

後処理

  1. customaccording to General Method 4B at 120° C

出典と根拠

ORDレコード
ord-0ebd5d658add447c96942101750407a7
出典データセット
uspto-grants-2016_09
特許番号
US09434690B2

反応ノート

読み込み中…