Dimethyl Sulfoxide → 3-(2,2,3,3,3-Pentafluoropropoxy)phthalonitrile

HRID 566844

反応式

HRID 566844 の反応式
[N+]([C:4]1[CH:11]=[CH:10][CH:9]=[C:6]([C:7]#[N:8])[C:5]=1[C:12]#[N:13])([O-])=O.[F:14][C:15]([F:22])([C:18]([F:21])([F:20])[F:19])[CH2:16][OH:17].C(=O)([O-])[O-].[K+].[K+].CS(C)=O>O>[F:14][C:15]([F:22])([C:18]([F:21])([F:20])[F:19])[CH2:16][O:17][C:4]1[CH:11]=[CH:10][CH:9]=[C:6]([C:7]#[N:8])[C:5]=1[C:12]#[N:13]

参加物

6

反応物 4

HCID 679Dimethyl SulfoxideHCID 98722,2,3,3,3-PentafluoropropanolHCID 11430Potassium CarbonateHCID 1626521,2-Benzenedicarbonitrile, 3-nitro-

生成物 1

HCID 212636413-(2,2,3,3,3-Pentafluoropropoxy)phthalonitrile収率 95.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
50 °C

実験手順

A reaction flask was loaded with 8.7 g of 3-nitrophthalonitrile, 9.0 g of 2,2,3,3,3-pentafluoropropanol, 13.8 g of anhydrous potassium carbonate, and 350 ml of dimethyl sulfoxide, and the temperature was raised to 50° C. with stirring under nitrogen flow. After stirring at 50° C. for 4 hours, the heating was stopped. The reaction liquid was cooled and added into 500 ml of water, and the precipitated crystal was collected and dried to yield 13.2 g of the intended compound.

後処理

  1. stirringAfter stirring at 50° C. for 4 hours
  2. customThe reaction liquid
  3. temperaturewas cooled
  4. customthe precipitated crystal was collected
  5. customdried

出典と根拠

ORDレコード
ord-2ccaff9a2fb646c0aab682f52ccb1819
出典データセット
uspto-grants-2001_01
特許番号
US06177132B1

関連ノート

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