関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethyl Sulfoxide | HCID 679 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Trifluoromethylphenol | HCID 67958 | — |
| 反応物 | 1,2-Benzenedicarbonitrile, 3-nitro- | HCID 162652 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-[2-(Trifluoromethyl)phenoxy]phthaionitrile | HCID 70218787 | 93.2% |
反応手順
A reaction flask equipped with a cooling tube was loaded with 8.7 g of 3-nitrophthalonitrile, 9.4 g of 2-(trifluoromethyl)phenol, 13.8 g of anhydrous potassium carbonate and 350 ml of dimethyl sulfoxide, and the temperature was raised to 50° C. with stirring under nitrogen flow. After stirring at 50° C. for three hours, the heating was stopped. The reaction liquid was cooled and added into 500 ml of water, and the precipitated crystal was collected and dried to yield 13.5 g of the intended compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06177132B1 |
|---|
| 出典データセット | uspto-grants-2001_01 |
|---|
| ORD ID | ord-94338cd70cd04a0594a4c0519c257649 |
|---|
| 出典メモ | uspto-grants-2001_01 |
|---|
