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Tetrahydrofuran → 2-Fluoro-9-phenylfluoren-9-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Fluorofluorenone | HCID 70093312 | — |
| 反応物 | HCID 178506676 | HCID 178506676 | — |
| 溶媒 | Cyclohexane diethylether | HCID 21895417 | — |
| 生成物 | 2-Fluoro-9-phenylfluoren-9-ol | HCID 21263963 | 90% |
反応手順
To a stirred, ice-cooled solution of 2-fluorofluorenone (2.0 g, 10 mmol) in 15 mL of dry THF under N2 was added 10 mL of 2.4 M phenyllithium solution in cyclohexane-Et2O (7:3), keeping T<20° C. The mixture was quenched with water and the product isolated with EtOAc and purified by flash chromatography (7% EtOAc-hexanes) to give 2.52 g (90%) of 2-fluoro-9-phenylfluoren-9-ol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06177427B1 |
| 出典データセット | uspto-grants-2001_01 |
| ORD ID | ord-28b14d14aa0040648ba12bf59967ae09 |
| 出典メモ | uspto-grants-2001_01 |