化工社化工社 化学情報印刷レポート · 研究参考用
2-Bromo-4-chlorobenzonitrile → 4-Chloro-2-(5-fluoro-2-methoxypyridin-4-yl)benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Bromo-4-chlorobenzonitrile | HCID 23498524 | — |
| 反応物 | (5-Fluoro-2-methoxypyridin-4-yl)boronic acid | HCID 44754837 | — |
| 生成物 | 4-Chloro-2-(5-fluoro-2-methoxypyridin-4-yl)benzonitrile | HCID 117604844 | — |
反応手順
256 mg (1.5 mmol) of 5-fluoro-2-methoxypyridin-4-ylboronic acid and 295 mg (1.34 mmol) of 2-bromo-4-chlorobenzonitrile were reacted according to General Method 2A. The product was precipitated with water. Yield: 146 mg (37% of theory)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434690B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-aad9eac189c54f3bbd710f994a998d10 |
| 出典メモ | uspto-grants-2016_09 |