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Naphthalic anhydride, 3-nitro- → 2-Tert-butyldimethylsilyoxy-5-nitro-benzo[de]isoquinoline-1,3-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Naphthalic anhydride, 3-nitro- | HCID 18194 | — |
| 反応物 | O-(tert-Butyldimethylsilyl)hydroxylamine | HCID 4691350 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 2-Tert-butyldimethylsilyoxy-5-nitro-benzo[de]isoquinoline-1,3-dione | HCID 131722278 | 85.1% |
反応手順
O-(tert-Butyldimethyl-silyl)hydroxylamine (1.8 g, 12.3 mmol) was added to a solution of 3-nitro-1,8-naphthalic anhydride (2.0 g, 8.2 mmol) in 50 mL of pyridine. The solution was refluxed for 4 hours and concentrated in vacuo. Purification as described in Example A-1 gave 2.6 g of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06177423B1 |
| 出典データセット | uspto-grants-2001_01 |
| ORD ID | ord-08316885c60c4f95938146a1dd7a2269 |
| 出典メモ | uspto-grants-2001_01 |