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(5-Chloro-2-methoxypyridin-4-yl)boronic acid → 5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]-2-methoxypyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (5-Chloro-2-methoxypyridin-4-yl)boronic acid | HCID 11030558 | — |
| 反応物 | 2-Bromo-4-chloro-1-(difluoromethyl)benzene | HCID 66744942 | — |
| 生成物 | 5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]-2-methoxypyridine | HCID 117604825 | — |
反応手順
463 mg (purity 93%, 2.3 mmol) of (5-chloro-2-methoxypyridin-4-yl)boronic acid and 515 mg (2.1 mmol) of 2-bromo-4-chloro-1-(difluoromethyl)benzene in the presence of [1,1-bis(diphenylphosphino)ferrocene]palladium(II) chloride/dichloromethane monoadduct were reacted according to General Method 2A. Yield: 305 mg (purity 77%, 34% of theory)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434690B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-9f8edd3dd2a2499d8bb12cfe532680b7 |
| 出典メモ | uspto-grants-2016_09 |