(5-Chloro-2-methoxypyridin-4-yl)boronic acid → 5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]-2-methoxypyridine

HRID 56705

反応式

HRID 56705 の反応式
[Cl:1][C:2]1[C:3](B(O)O)=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1.Br[C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:15]=1[CH:21]([F:23])[F:22]>>[Cl:1][C:2]1[C:3]([C:14]2[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:15]=2[CH:21]([F:23])[F:22])=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1

参加物

3

反応物 2

HCID 11030558(5-Chloro-2-methoxypyridin-4-yl)boronic acidHCID 667449422-Bromo-4-chloro-1-(difluoromethyl)benzene

生成物 1

HCID 1176048255-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]-2-methoxypyridine

実験手順

463 mg (purity 93%, 2.3 mmol) of (5-chloro-2-methoxypyridin-4-yl)boronic acid and 515 mg (2.1 mmol) of 2-bromo-4-chloro-1-(difluoromethyl)benzene in the presence of [1,1-bis(diphenylphosphino)ferrocene]palladium(II) chloride/dichloromethane monoadduct were reacted according to General Method 2A. Yield: 305 mg (purity 77%, 34% of theory)

出典と根拠

ORDレコード
ord-9f8edd3dd2a2499d8bb12cfe532680b7
出典データセット
uspto-grants-2016_09
特許番号
US09434690B2

関連ノート

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