化工社化工社 化学情報印刷レポート · 研究参考用
Einecs 211-027-4 → 5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]pyridin-2(1H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Einecs 211-027-4 | HCID 69401 | — |
| 反応物 | 5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]-2-methoxypyridine | HCID 117604825 | — |
| 生成物 | 5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]pyridin-2(1H)-one | HCID 117605586 | — |
反応手順
305 mg (purity 77%, 0.77 mmol) of 5-chloro-4-[5-chloro-2-(difluoromethyl)phenyl]-2-methoxypyridine and 20 eq. of pyridinium chloride were reacted according to General Method 3A. After work-up, the crude product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient). Yield: 179 mg (80% of theory)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434690B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-b098b5f42e87484490369782a0a6d1f2 |
| 出典メモ | uspto-grants-2016_09 |