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2-Bromopropionic acid → 2-{5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}propanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Bromopropionic acid | HCID 11729 | — |
| 反応物 | 5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]pyridin-2(1H)-one | HCID 117605586 | — |
| 生成物 | 2-{5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}propanoic acid | HCID 117622899 | — |
反応手順
118 mg (0.41 mmol) of 5-chloro-4-[5-chloro-2-(difluoromethyl)phenyl]pyridin-2(1H)-one and 1.5 eq. of 2-bromopropanoic acid (racemate) were reacted according to General Method 4A at 35° C. Yield: 112 mg (76% of theory)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434690B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-f46809968d4f4934871de5b1cc97ab55 |
| 出典メモ | uspto-grants-2016_09 |