反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7](B(O)O)[C:6]([C:12]([F:15])([F:14])[F:13])=[CH:5][N:4]=1.Br[C:17]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:18]=1[C:19]#[N:20]>>[Cl:25][C:23]1[CH:24]=[CH:17][C:18]([C:19]#[N:20])=[C:21]([C:7]2[C:6]([C:12]([F:15])([F:14])[F:13])=[CH:5][N:4]=[C:3]([O:2][CH3:1])[CH:8]=2)[CH:22]=1参加物
3
実験手順
1.0 g (4.4 mmol) of 2-methoxy-5-trifluoromethylpyridin-4-ylboronic acid and 0.95 g (4.4 mmol) of 2-bromo-4-chlorobenzonitrile in the presence of [1,1-bis(diphenylphosphino)ferrocene]palladium(II) chloride/dichloromethane monoadduct were reacted according to General Method 2A. Yield: 351 mg (purity 71%, 18% of theory)
出典と根拠
- ORDレコード
- ord-1fa0044468674d8d8fcdb79c4ca3d961
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434690B2
関連ノート
読み込み中…