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2-Bromo-4-chlorobenzonitrile → 4-Chloro-2-(2,5-dimethoxypyridin-4-yl)benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Bromo-4-chlorobenzonitrile | HCID 23498524 | — |
| 反応物 | 2,5-Dimethoxypyridine-4-boronic acid | HCID 74890663 | — |
| 生成物 | 4-Chloro-2-(2,5-dimethoxypyridin-4-yl)benzonitrile | HCID 117605216 | — |
反応手順
7.87 g (purity 95%, 40.86 mmol) of 2,5-dimethoxypyridin-4-ylboronic acid and 8.85 g (40.86 mmol) of 2-bromo-4-chlorobenzonitrile in the presence of [1,1-bis(diphenylphosphino)ferrocene]palladium(II) chloride/dichloromethane monoadduct were reacted according to General Method 2A. Yield: 6.23 g (purity 92%, 51% of theory)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434690B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-e22a23f4a69c40a29f6214214a1fd8be |
| 出典メモ | uspto-grants-2016_09 |