化工社化工社 化学情報印刷レポート · 研究参考用
2-Bromo-4-chloro-1-nitrobenzene → 4-(5-Chloro-2-nitrophenyl)-2,5-dimethoxypyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Bromo-4-chloro-1-nitrobenzene | HCID 9856124 | — |
| 反応物 | 2,5-Dimethoxypyridine-4-boronic acid | HCID 74890663 | — |
| 触媒 | XPhos Palladacycle | HCID 54751079 | — |
| 生成物 | 4-(5-Chloro-2-nitrophenyl)-2,5-dimethoxypyridine | HCID 117605401 | — |
反応手順
215 mg (purity 85%, 1.0 mmol) of 2,5-dimethoxypyridin-4-ylboronic acid and 236 mg (1.0 mmol) of 2-bromo-4-chloro-1-nitrobenzene in the presence of XPhos precatalyst were reacted according to General Method 2B. Yield: 124 mg (purity 93%, 39% of theory)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434690B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-4cb486254e834e36939cd0a934f823a0 |
| 出典メモ | uspto-grants-2016_09 |