2-Bromo-4-chloro-1-nitrobenzene → 4-(5-Chloro-2-nitrophenyl)-2,5-dimethoxypyridine

HRID 56739

反応式

HRID 56739 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7](B(O)O)[C:6]([O:12][CH3:13])=[CH:5][N:4]=1.Br[C:15]1[CH:20]=[C:19]([Cl:21])[CH:18]=[CH:17][C:16]=1[N+:22]([O-:24])=[O:23]>CC(C1C=C(C(C)C)C(C2C(P(C3CCCCC3)C3CCCCC3)=CC=CC=2)=C(C(C)C)C=1)C.C1C=[C-]C(CCN)=CC=1.Cl[Pd+]>[Cl:21][C:19]1[CH:18]=[CH:17][C:16]([N+:22]([O-:24])=[O:23])=[C:15]([C:7]2[C:6]([O:12][CH3:13])=[CH:5][N:4]=[C:3]([O:2][CH3:1])[CH:8]=2)[CH:20]=1

参加物

4

反応物 2

HCID 98561242-Bromo-4-chloro-1-nitrobenzeneHCID 748906632,5-Dimethoxypyridine-4-boronic acid

生成物 1

HCID 1176054014-(5-Chloro-2-nitrophenyl)-2,5-dimethoxypyridine

試薬・触媒・溶媒 1

HCID 54751079XPhos Palladacycle触媒

実験手順

215 mg (purity 85%, 1.0 mmol) of 2,5-dimethoxypyridin-4-ylboronic acid and 236 mg (1.0 mmol) of 2-bromo-4-chloro-1-nitrobenzene in the presence of XPhos precatalyst were reacted according to General Method 2B. Yield: 124 mg (purity 93%, 39% of theory)

出典と根拠

ORDレコード
ord-4cb486254e834e36939cd0a934f823a0
出典データセット
uspto-grants-2016_09
特許番号
US09434690B2

関連ノート

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