化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Hydroxide → Isotretinoin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 1,4-Pentadien-3-ol, 3-methyl-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)- | HCID 6436846 | — |
| 反応物 | Triphenylphosphinehydrochloride | HCID 12196763 | — |
| 反応物 | Hydroxy butenolide | HCID 21773091 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Isotretinoin | HCID 5282379 | — |
反応手順
43 g of the mixture of retinoic acids from the condensation of hydroxy butenolide, vinyl beta-ionol and triphenylphosphine hydrochloride in 10 ml of ethanol are treated with 15 g of a 50% potassium hydroxide aqueous solution, subsequently diluted to 200 mL with water, added with 30 mg of Bengal rose, then irradiated with a 18 Watt lamp for 12 hours.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06177579B1 |
| 出典データセット | uspto-grants-2001_01 |
| ORD ID | ord-53c33f094f89499a89ea20c9541d821d |
| 出典メモ | uspto-grants-2001_01 |