Methyl morpholine oxide → 5-Hydroxy-2-methoxypyridine
反応式
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1.C[N+]1([O-])CC[O:16]CC1>ClCCl>[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([OH:16])=[CH:5][CH:4]=1参加物
4
反応条件
- 温度
- 50 °C
実験手順
At RT, 50 g (327 mmol) of 6-methoxypyridin-3-ylboronic acid were added to a solution of 46.0 g (392 mmol) of N-methylmorpholine N-oxide in 500 ml of dichloromethane, and the mixture was stirred at 50° C. for 14 h. Additional N-methylmorpholine N-oxide was added until the reaction had gone to completion. The reaction mixture was concentrated under reduced pressure and the crude product was purified by flash chromatography (silica gel 60, cyclohexane/ethyl acetate mixtures). Yield: 32.9 g (80% of theory)
後処理
- concentrationThe reaction mixture was concentrated under reduced pressure
- customthe crude product was purified by flash chromatography (silica gel 60, cyclohexane/ethyl acetate mixtures)
出典と根拠
- ORDレコード
- ord-873065e9d4b141dcac24f012c4cf7220
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434690B2
反応ノート
読み込み中…