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Nitrogen → 2-(2,6-Difluoro-phenyl)-6-nitro-benzo[d][1,3]oxazin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Nitrogen | HCID 947 | — |
| 反応物 | 2-Amino-5-nitrobenzoic acid | HCID 12032 | — |
| 反応物 | 2,6-Difluorobenzoyl chloride | HCID 87438 | — |
| 溶媒 | Toluene triethylamine | HCID 22504574 | — |
| 生成物 | 2-(2,6-Difluoro-phenyl)-6-nitro-benzo[d][1,3]oxazin-4-one | HCID 21262464 | — |
反応手順
5-Nitroanthranilic acid (0.6 g) was dissolved in triethyl amine/toluene (1/1) (18 mL) and stirred for 10 min. 2,6-Difluorobenzoylchloride (1.3 g) was slowly added under stirring which resulted in the formation of a precipitate. The reaction was performed in an N2-atmosphere. After stirring at RT for 24 h the mixture was extracted with sat.NaHCO3 and ethyl acetate (20 mL), the organic layer was separated and evaporated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06180625B2 |
| 出典データセット | uspto-grants-2001_01 |
| ORD ID | ord-799a40c324144e02bf5f287d1693f394 |
| 出典メモ | uspto-grants-2001_01 |