2,6-Difluorobenzoyl chloride → 2-(2,6-Difluoro-phenyl)-5-methyl-benzo[d][1,3]oxazin-4-one

反応式

[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:3]=1[C:4]([OH:6])=[O:5].[F:12][C:13]1[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[C:14]=1[C:15](Cl)=O.C(NC1C=CC2N=C(C3C(F)=CC=CC=3F)OC(=O)C=2C=1)(=O)C>C(N(CC)CC)C.C1(C)C=CC=CC=1>[F:12][C:13]1[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[C:14]=1[C:15]1[O:5][C:4](=[O:6])[C:3]2[C:7]([CH3:11])=[CH:8][CH:9]=[CH:10][C:2]=2[N:1]=1

参加物

実験手順

2-Amino-6-methylbenzoic acid (0.498 g), 2,6-difluorobenzoyl chloride (0.93 mL) and triethyl amine/toluene (1/1) (20 mL) were reacted as described under (10).

出典と根拠

ORDレコード: ord-3b042ae8eaad4006bc28228c70a460e6
出典データセット: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06180625B2

反応ノート

読み込み中…

参加物

反応物 3

HCID 874382,6-Difluorobenzoyl chloride

HCID 1512106-Methylanthranilic acid

HCID 99488136-Acetamido-(2,6-difluoro-phenyl)-benzo[d][1,3]oxazin-4-one

生成物 1

HCID 212624792-(2,6-Difluoro-phenyl)-5-methyl-benzo[d][1,3]oxazin-4-one

試薬・触媒・溶媒 1

HCID 22504574Toluene triethylamine溶媒

実験手順

2-Amino-6-methylbenzoic acid (0.498 g), 2,6-difluorobenzoyl chloride (0.93 mL) and triethyl amine/toluene (1/1) (20 mL) were reacted as described under (10).

出典と根拠

ORDレコード: ord-3b042ae8eaad4006bc28228c70a460e6
出典データセット: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06180625B2

反応ノート

読み込み中…