化工社化工社 化学情報印刷レポート · 研究参考用
Benzene, 1-isocyanato-2-methoxy- → CXCR2 antagonist 8
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzene, 1-isocyanato-2-methoxy- | HCID 69695 | — |
| 反応物 | 2-Amino-5-Nitrophenol | HCID 4984721 | — |
| 生成物 | CXCR2 antagonist 8 | HCID 9796445 | 27% |
反応手順
N-(2-Hydroxy-4-nitrophenyl)-N′-(2-methoxyphenyl)urea was prepared from 2-hydroxy 4-nitro aniline (154 mg, 1.0 mmol) and 2-methoxyphenylisocyanate(1 mmol.) according to the procedure in General Method B. The product was purified by dilution with methylene chloride and precipitation with hexanes. Filtering afforded the title compound (82 mg, 27%). EI-MS m/z 302(M−H)−.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06180675B2 |
| 出典データセット | uspto-grants-2001_01 |
| ORD ID | ord-5e529a6bacf64ef1b28402f246b73c7a |
| 出典メモ | uspto-grants-2001_01 |