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Water → 1,3-Di-cyclopropylmethyl-8-chloroxanthine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Chlorine monoxide | HCID 24646 | — |
| 反応物 | 1,3-Dicyclopropylmethyl-8-nitro xanthine | HCID 9857658 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1,3-Di-cyclopropylmethyl-8-chloroxanthine | HCID 9814657 | — |
反応手順
1,3-Di-cyclopropylmethyl-8-nitro xanthine (6 g, 0.023 mol) was dissolved in dimethylformamide (20 ml) and reacted with phosporous oxychloride (14 g) for 1 hour at 120° C. The mixture was then treated with water and stirred for 1 hour at room temperature. The precipitate was filtered off, dissolved in ethyl acetate, dried over anhydrous sodium sulphate and the solvent was removed in vacuo, yield 2.5 g (40%), m.pt. 220° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06180791B2 |
| 出典データセット | uspto-grants-2001_01 |
| ORD ID | ord-efb273a559134d5384e8ba63e452f377 |
| 出典メモ | uspto-grants-2001_01 |