関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 反応物 | ethyl 4,6-dichloro-1H-indole-2-carboxylate | HCID 2736407 | — |
| 溶媒 | 1,1-Dichloroethane | HCID 6365 | — |
| 生成物 | ethyl 4,6-dichloro-3-formyl-1H-indole-2-carboxylate | HCID 2794948 | — |
反応手順
Combine 2-carboethoxy-4,6-dichloroindole (10.0 g, 0.039 mol), and dimethylformamide (4.5 mL, 0.057 mol) in dichloroethane (20 mL). Add phosphoryl chloride (8.9 g, 0.058 mmol). Heat to 80° C. After 18 hours, cool the reaction mixture to ambient temperature and combine with aqueous 1 M sodium acetate solution and stir. After 18 hours, filter, rinse with water, and dry to give 3-formyl-2-carboethoxy-4,6-dichloroindole.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06180786B2 |
|---|
| 出典データセット | uspto-grants-2001_01 |
|---|
| ORD ID | ord-e8efce8ed6ef48ca829ab6cf28d56553 |
|---|
| 出典メモ | uspto-grants-2001_01 |
|---|
