Formic Acid → Acetic anhydride formic acid
反応式
[CH:1]([OH:3])=[O:2].[C:4]([O:7][C:8](=[O:10])[CH3:9])(=[O:6])[CH3:5]>>[CH:1]([OH:3])=[O:2].[C:4]([O:7][C:8](=[O:10])[CH3:9])(=[O:6])[CH3:5]参加物
3
反応条件
- 温度
- 50 °C
実験手順
Formic acid (0.5 ml, 13.3 mmol) was added to acetic anhydride (1.0 ml, 10.6 mmol) under ice-cooling, the mixture was stirred for one hour at 50° C. to give formic acid-acetic acid anhydride. To a tetrahydrofuran (10 ml) solution of the compound 2 (200 mg, 0.34 mmol) obtained in Example 10 was added the formic acid-acetic acid anhydride (0.3 ml) under ice-is cooling and the mixture was stirred for 30 minutes. The mixture was stirred for one hour. The reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give colorless solid substance (125 mg) of the titled compound.
後処理
- temperaturecooling
出典と根拠
- ORDレコード
- ord-bd38bd8caf6544858811c5766937c057
- 出典データセット
- uspto-grants-2001_01
- 特許番号
- US06180792B2
反応ノート
読み込み中…