Triphenylphosphine → HCID 21262400、化合物

HRID 568289ノート

反応式

HRID 568289 の反応式
[C:1]1([P:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:20].O[CH2:22][C:23]1[N:30]2[C:26]([S:27][CH:28]=[CH:29]2)=[CH:25][N:24]=1>CN(C=O)C>[Cl-:20].[S:27]1[CH:28]=[CH:29][N:30]2[C:23]([CH2:22][P+:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[N:24][CH:25]=[C:26]12

参加物

4

反応物 2

HCID 11776TriphenylphosphineHCID 212624205-Hydroxymethylimidazo[5,1-b]thiazole hydrochloride

生成物 1

HCID 21262400HCID 21262400、化合物収率 74.8%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

Triphenylphosphine (2.51 g) is added to a solution of 1.23 g of 5-hydroxymethylimidazo[5,1-b]thiazole hydrochloride in 20 ml of DMF, and the mixture is stirred at 100° C. for 12 hr. The solvent is removed by evaporation, and the residue is purified by column chromatography on silica gel (methanol:dichloromethane=5:95) to give 2.1 g of (imidazo[5,1-b]thiazol-5-yl)methyltriphenylphosphonium chloride.

後処理

  1. customThe solvent is removed by evaporation
  2. customthe residue is purified by column chromatography on silica gel (methanol:dichloromethane=5:95)

出典と根拠

ORDレコード
ord-bee344253a114652aa644988784cd612
出典データセット
uspto-grants-2001_01
特許番号
US06180622B2

反応ノート

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