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Sodium Hydroxide → 6-Bromo-2-methoxyquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1) | HCID 2735153 | — |
| 反応物 | 6-Bromoquinolin-2(1H)-one | HCID 12378943 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 6-Bromo-2-methoxyquinoline | HCID 10657538 | — |
反応手順
A mixture of 6-bromo-2-[1H]-quinolone (2.90 g) and trimethyloxoniumtetrafluoroborate (2.10 g) was stirred in dichloromethane (50 cm3) for 48 hours under nitrogen. Aqueous 10% sodium hydroxide (20 cm3) was added and the aqueous phase was extracted with dichloromethane (2×40 cm3). The dried (MgSO4) extracts were evaporated and the residue was crystallised from petroleum ether (b.p. 60°-80°) to yield the title compound, m.p. 90°-94°, (2.16 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04728654 |
| 出典データセット | uspto-grants-1988_03 |
| ORD ID | ord-ea325e0a646141b6b088ce1a3b429975 |
| 出典メモ | uspto-grants-1988_03 |