Water → 1-Methyl-2-methylsulfonyl-4-nitroimidazole

反応式

[I-].[K+].C[N:4]1[C:8]([N+:9]([O-:11])=[O:10])=[CH:7][N:6]=[C:5]1[S:12]([CH3:15])(=[O:14])=[O:13].O.[CH3:17]N(C)C=O>>[CH3:17][N:6]1[CH:7]=[C:8]([N+:9]([O-:11])=[O:10])[N:4]=[C:5]1[S:12]([CH3:15])(=[O:13])=[O:14]

参加物

反応物 4

HCID 962Water

HCID 4875Potassium Iodide

HCID 6228Dimethylformamide

HCID 100595Sulfonidazole

生成物 1

HCID 3316921-Methyl-2-methylsulfonyl-4-nitroimidazole

反応条件

温度: 160 °C

実験手順

Potassium iodide (4.8 g) and 1-methyl-2-methylsulfonyl-5-nitroimidazole (5.0 g) were combined in N,N-dimethylformamide (30 ml) and the reaction mixture heated to 160° C. for 2 hours. Upon cooling, the reaction mixture was added to 150 ml of a water and ice mixture. The product precipitated and was filtered and dried affording 4.4 g of 1-methyl-2-methylsulfonyl-4-nitroimidazole.