(E)-4-(1H-imidazol-1-yl)-2-butenamine → HCID 178456322、化合物

HRID 568491ノート

反応式

HRID 568491 の反応式
[N:1]1([CH2:6]/[CH:7]=[CH:8]/[CH2:9][NH2:10])[CH:5]=[CH:4][N:3]=[CH:2]1.[IH:11].CS[C:14]1[C:22]2[CH:23]=[CH:24][CH:25]=[C:20]3[C:21]=2[C:16](=[CH:17][CH:18]=[CH:19]3)[N:15]=1>C(O)C>[IH:11].[N:1]1([CH2:6]/[CH:7]=[CH:8]/[CH2:9][NH:10][C:14]2[C:22]3[CH:23]=[CH:24][CH:25]=[C:20]4[C:21]=3[C:16](=[CH:17][CH:18]=[CH:19]4)[N:15]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

参加物

4

反応物 2

HCID 13371079(E)-4-(1H-imidazol-1-yl)-2-butenamineHCID 201506502-Methylthiobenz(cd)indole hydriodide

生成物 1

HCID 178456322HCID 178456322、化合物収率 63.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
-10 °C

実験手順

A mixture of 5.0 g of (E)-4-(1H-imidazol-1-yl)-2-butenamine, 11.5 g of 2-(methylthio)benz[cd]indole hydroiodide and 400 ml of ethanol was stirred and heated at reflux for 16 hours, then clarified while hot. The filtrate was concentrated to 250 ml, cooled to -10° C. and the resulting solid collected, washed with ethanol, ether and dried at 60° C. in vacuo, giving 9.3 g of the desired product, mp 152°-155° C. (dec.).

後処理

  1. temperatureheated
  2. temperatureat reflux for 16 hours
  3. concentrationThe filtrate was concentrated to 250 ml
  4. customthe resulting solid collected
  5. washwashed with ethanol, ether
  6. customdried at 60° C. in vacuo

出典と根拠

ORDレコード
ord-68081b6f88f141f8bbfdbcfad243a3dd
出典データセット
uspto-grants-1988_03
特許番号
US04728663

反応ノート

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