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Acetonitrile → 2-Thenoylacetonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Ethyl 2-thenoate | HCID 76052 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-Thenoylacetonitrile | HCID 141853 | 92.6% |
反応手順
78.1 grams (0.5 mole) of thiophene-2-carboxylic acid ethyl ester and 30 grams (1 mole) of sodium hydride (80% suspension in white oil) were reacted with 41.5 grams (1 mole) of acetonitrile in 500 ml of dry toluene. There were obtained 70.0 grams (92.6% of theory) of 2-thiophenoylacetonitrile having a melting point of 110° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04728743 |
| 出典データセット | uspto-grants-1988_03 |
| ORD ID | ord-6134339ac3da40398099f92e3039b85c |
| 出典メモ | uspto-grants-1988_03 |